Abstract
Abstract Antihyaluronidase in the serum of fifty normal human beings antagonistic to Type 2 pneumococcus hyaluronidase was compared with the same antihyaluronidase in the serum of Patient A. T. who was six months convalescent from Type 2 pneumococcus endocarditis. All of the fifty normal subjects tested had some degree of this antihyaluronidase. Since subsequent experiments demonstrated that serum antihyaluronidase antagonistic to pneumococcus hyaluronidase is not type specific, these observations upon the sera of normal human beings pertain to hyaluronidase elaborated by all types of pneumococci. Serial sera of twenty-six patients with primary pneumococcic pneumonia were tested for antihyaluronidase by titration against hyaluronidases in culture filtrates of Type 1, Type 2, and Type 7 pneumococci. Seven patients with negative blood culture and no purulent complication exhibited no change of antihyaluronidase titer. Eight of eleven patients with pneumococcus bacteremia and no purulent complication exhibited rises of antihyaluronidase titer which were fourfold or greater. All of eight patients with pneumococcus bacteremia and purulent complication exhibited rises of titer of fourfold or greater. The rises of antihyaluronidase titer which were observed were not specific for pneumococcus type. Therapeutic antipneumococcic rabbit serum exhibited less antagonism of pneumococcus hyaluronidase than did a majority of the sera from fifty normal human beings. High therapeutic concentrations of penicillin and sodium sulfadiazine exhibited no antagonism of pneumococcus hyaluronidase. A rise of serum antihyaluronidase titer could not be brought about in one patient with pneumococcic pneumonia by the intravenous administration of therapeutic antipneumococcic serum, but a progressive rise of serum agglutinin titer for the homologous pneumococcus was produced.
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