Abstract
AKNOWLEDGE of the nature of the inhibitory substances produced in response to injections of various endocrine materials is necessary before the physiological significance of these so-called antihormones can be stated. Although many approaches to this problem have been employed, the question has not yet been definitely settled, and the reader is referred to the recent excellent reviews on the subject (i, 2). One method of attack, not sufficiently investigated, has been to determine the relative amounts of antihormone evoked by hormone preparations of different degrees of purity. Thus, for example, Rowlands and Young (3) have reported that administration to rabbits of a crude pyridine extract of ox anterior lobe resulted in the production of greater amounts of antithyrotropic substance than did a purified thyrotropic preparation. Such findings are interpreted as supporting the contention that the antihormones are antibody in nature.
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