Abstract
A new highly oxygenated triterpene named ganoderic acid α has been isolated from a methanol extract of the fruiting bodies of Ganoderma lucidum together with twelve known compounds. The structures of the isolated compounds were determined by spectroscopic means including 2D-NMR. Ganoderiol F and ganodermanontriol were found to be active as anti-HIV-1 agents with an inhibitory concentration of 7.8 μg ml −1 for both, and ganoderic acid B, ganoderiol B, ganoderic acid C1, 3 β-5 α-dihydroxy-6 β-methoxyergosta-7,22-diene, ganoderic acid α, ganoderic acid H and ganoderiol A were moderately active inhibitors against HIV-1 PR with a 50% inhibitory concentration of 0.17–0.23 mM.
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