Abstract
AbstractThis research investigated the modulating effects of antihistamines—Loratadine, Fexofenadine, Meclizine, and Chlorpheniramine on cognitive (executive function, memory, attention, emotion regulation), mood, psychomotor performance, and sedation in healthy human volunteers. Twenty healthy volunteers received Loratadine 10-mg, Fexofenadine 120-mg, Meclizine 50-mg, Chlorpheniramine Maleate 4-mg, and Placebo 250-mg starch tablet in a five-way crossover, double-blind study. Following each dose the participants were subjected to take a series of test of cognitive functions and psychomotor performances at defined interval. A certain amount of washout period was also maintained for each drug. The test battery included PennCNP—Full Battery Test, Psychology Experiment Building Language, Stanford Sleepiness Scale, and Brief Mood Introspection Scale. The test results These test results were analyzed by one-way and two-way ANOVAs. In general, antihistamines didn't show any statistically significant deviation fr...
Highlights
Antihistamines are drugs that antagonize the effects of histamines
We investigate the effects of antihistamines—Loratadine, Fexofenadine, Meclizine, and Chlorpheniramine on cognitive performance and psychomotor performance on healthy human volunteers
Immediate and delayed recall word memory test In immediate word memory test, a one-way ANOVA was conducted to compare the effect of antihistamines between subjects and placebo on immediate recall word memory test
Summary
Antihistamines are drugs that antagonize the effects of histamines They are widely used in relieving allergic symptoms. They have adverse effects in the central nervous system (Gengo, 1996). They are mostly used to provide symptomatic relief from allergic symptoms caused by histamine release (Dridi, Ben Attia, Reinberg, & Boughattas, 2005). Antihistamines are widely used in treating various allergic diseases They can cross the blood–brain barrier and block histaminergic receptors and other neurotransmitters (e.g. serotonin, choline, noradrenaline) in the brain, and as a consequence produce sleepiness, drowsiness, fatigue, and sedation (Passalacqua et al, 1996; Snyder & Snowman, 1987), which lead to cognitive and psychomotor impairment (Hindmarch, 1995; Kay, 2000). Third-generation antihistamines don’t impair cognitive and psychomotor performances (Hindmarch, Shamsi, & Kimber, 2002) and do not have any sedative effects (Hindmarch, 2002)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
