Abstract
Introduction: The present study was undertaken to evaluate the protective acti vity of 95% hydroalcoholic extract of Barleria Montana leaves against anti - TB drugs induced hepatotoxicity. Methods: Hepatotoxicity wa s i nduced by anti - TB drugs once daily for 35 days and simultaneously 95% hydroalcoholic extract of Barleria Montana (250 & 500 mg/kg p.o.) was administered one hour prior admin istration of anti - TB drugs. Silymarin was used as standard drug (100 mg/kg p.o.). Results: Elevated levels of SGOT, SGPT, ALP, TB & total cholesterol and decreased total HDL following anti - TB drugs admi nistration. Pretreatment of 95% hydroalcoholic extract of Barleria Montana with anti - TB drugs were significantly reduced biochemical markers and increased total HDL. In vivo antioxidant parameters such as SOD, CAT, GSH, GPx and GRx were suppressed in hepat ic control animals. Pre treatment of 95% hydroalcoholic extract of Barleria Montana with anti - TB drugs significantly reduced lipid per oxidation and increased antioxidant activities. Conclusion: The result of the present study was indicated that B arleria M ontana showed protective effect on li ver toxicity induced by anti - TB drugs might be attributed to its antioxidant activity.
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