Abstract
We isolated a sterol glucoside from ethanol extract of aerial parts of Clerodendrum phlomidis. Chemical structure was identified as 24-ethyl-cholesta-5(6), 22(23), 25(26)-triene-3-O-β-d-glucopyranoside was a rare glucoside of 22-dehydroclerosterol. It was isolated for the first time from this plant. Compound (1) has shown significant antihepatotoxic activity by decreasing the elevated levels of serum enzymes such as serum glutamate oxaloacetate transaminase (SGOT) by 57.71%, serum glutamate pyruvate oxaloacetate transaminase (SGPT) by 52.25%, and alkaline phosphatase (ALP) by 93.14%; while the total protein (TP) levels were increased by 100.47%, When compared with standard drug silymarin that have decreased SGOT by 77.03%, SGPT by 69.67%, ALP by 93.14%, and increased TP levels by 100.47%, against CCl4-induced toxicity in albino wistar rats. The biochemical parameters also showed the significant antihepatotoxic activity.
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