Abstract
IN a recent communication1, I described the effect of certain conditions on the stability of freeze-dried factor VIII (antihaemophilic globulin). Owing to the antigenicity of animal material and the restricted supply of human factor2, other sources of this labile factor have been sought. Plasma, kept frozen after being separated from fresh blood, is now being widely utilized in the management of haemophilia. This raises for consideration the effect of different methods of freezing on factor VIII and other blood-clotting factors.
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