Abstract
In animals receiving gonadotrophic hormone regularly for a comparatively long time, the appropriate effect on the gonads may, under certain conditions, be induced during only a relatively short part of that time. In such conditions an initial period of increased endocrine function of the gonads is followed by a period of inactivity and ultimately by atrophy [McPhail, 1933]. Pari passu with the development of this refractory state the blood serum acquires the capacity to inhibit the activity of the gonadotrophic hormone in question, if the serum and hormone are injected into animals at separate sites. The conditions for development of antigonadotrophic sera require that the gonadotrophin shall have originated in the tissues of a species other than that of the animal yielding the serum. We found these antisera useful in identifying the species of origin of unknown gonadotrophic preparations, for example to see whether they had been extracted from pituitaries
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