Abstract
The antigenotoxic effect of rice extracts from Sung-Yod red rice cultivar produced in Thailand have been investigated in human lymphocytes for a sister chromatid exchange (SCE) assay in vitro. Pretreatment of 2 different fractions of the rice extracts, the rinsed water fraction (SYGW) and the aqueous extract of freeze dried boiled rice bran (SYBBOIL) at the concentrations of 6.25–100µg/ml alone for 2h followed by 0.1µg/ml doxorubicin as chemotherapeutic agent for 2h could not significantly reduce SCE level induced by doxorubicin (p<0.05). Our data indicated that rice extracts in the form of SYGW and SYBBOIL fractions can not protect human lymphocytes from genotoxic damage induced by 0.1µg/ml doxorubicin. In conclusion, our Sung-Yod rice extracts in the form of SYGW and SYBBOIL have no antigenotoxic potential against doxorubicin. However, their antigenotoxic potential is further investigated using other genotoxic compounds to investigate its benefit as herbal medicine.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
