Abstract
Summary Indirect immunofluorescence has been used to search for heart-specific antibodies in the sera of 35 rabbits and 42 human infants immunized with streptococcal M protein vaccines. No antibodies specific for human or rabbit myofibers were found in these immune sera. A survey of the sera of 150 acute rheumatic fever patients showed about 50% with heart-specific antibodies. Many of these sera also had high-titer antibodies to type 12 M protein. When these sera (first absorbed with liver powder) were absorbed with an antigenic excess of type 12 M protein, no significant diminution was observed in the intensity of the immunofluorescent heart staining reaction. These results indicate that purified M proteins are unrelated to those antigens of heart tissue that are shared with group A streptococci. The results are discussed in reference to the safety of antistreptococcal M protein vaccines.
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