Abstract
Antigenicity of the human zona pellucida was investigated. Rabbit antiserum against saline homogenates of human ovary yielded a minimum of 9 precipitin bands when reacted against human ovary in agar-gel double diffusion analyses. The same antiserum also cross-reacted in varying degrees when tested against 21 other human tissues and fluids. Anti-human-ovary serum was rendered specific to human ovary by absorption with human liver and plasma. Both unabsorbed and absorbed antisera reacted with isolated human zonae pellucidae as demonstrated by the formation of a precipitation layer on the zona and by the indirect fluorescent technique. These results demonstrated that the human ovary contains at least 1 antigen which is not found in 21 other human tissues and fluids tested and that the antiserum reacting with this ovarian antigen contains antibody activity directed against the zona pellucida.
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