Abstract
Abstract Three immunoglobulins were examined for their respective antigenic variation within the genus Peromyscus (white-footed mouse). Antigenic relationships among 7Sγ2, 7Sγ1 and γM globulins of 15 peromyscus species or subspecies were studied by using rabbit antisera specific for immunoglobulin from one of the species, Peromyscus maniculatus artemisiae (deer mouse). All peromyscus species tested contained antigenically similar 7Sγ2, 7Sγ1 and γM globulins. The γM globulins of all species or subspecies appeared identical to that of P. m. artemisiae. In contrast, 7Sγ2 globulins antigenically identical to those of P. m. artemisiae were found in only four peromyscus sera, which represented other subspecies of P. maniculatus. The 7Sγ1 globulins were antigenically identical in 12 of the peromycus, although the electrophoretic mobility of the 7Sγ1 globulin and its Fc piece differed from species to species. The results suggest that the structures of these immunoglobulins are evolving at dissimilar rates and 7Sγ2 globulin is undergoing more rapid evolutionary change than γM globulin.
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