Abstract
Summary Immunochemical analyses were made on tetanus neurotoxin using horse antitoxin serum. Three distinct antigenic determinants were found in the neurotoxin molecule: one (α) in fragment α, released with fragment β by mild trypsin treatment of the toxin, and two (β-1 and β-2) in two subfragments (β-1 and β-2) of fragment β. Two fragments were obtained by mild treatment of the toxin with papain; two determinants (α and β-2) were found in one fragment and one determinant (β-1) in the other fragment. No anti-α antibody was found in human antitoxin serum. Later a fourth, “conformation dependent” antigenic determinant (designated γ) was found in the whole toxin molecule. The structure of tetanus neurotoxin was discussed.
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