Abstract
Synthetic antigens consisting of dinitrophenyl groups attached to linear or branched-chain polyethylene oxide stimulate anti-DNP antibody production in rabbits and a proliferative response in vitro in immune rabbit lymphocytes. A requirement for immunogenicity is divalence. Linear DNP 2PEO is most effective at a molecular weight of 10 4, but a clear response is obtained even at 10 3. The optimal valence of DNP n PEO ( n = 4–80, MW, 4 × 10 5) is 20. Destruction of T cells with antithymocyte serum does not impair the in vitro response of the remaining B lymphocytes to DNP 2PEO, indicating that these antigens are T independent.
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