Abstract
A combinatorial mathematical model describing the antigenic relationships found between different avian paramyxovirus (PMV) serotypes (Lipkind and Shihmanter, 1986) is presented. According to the model, the network of the antigenic interconnections is determined by the specific combinatorial sets of antigenic determinants, some of them being serotype-specific and the others being common to certain other avian PMV serotypes. The suggested model is based on certain postulates concerning PMV virion structure; the bifunctional organization of PMV haemagglutinin-neuraminidase (HN) glycoprotein, its amount per virion and a mechanism of antibody-caused inhibition of its functional activities; the definition of an antigenic determinant as an elementary unit inducing and reacting only with a homologous type of antibodies. The model interprets in specific terms some serological results, in particular the old but mysterious phenomenon of asymmetric cross reactivity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
