Abstract
Abstract Antigenic characteristics of mouse fibrosarcomas induced by three strains of Rous sarcoma virus (Schmidt-Ruppin-, Prague- and Bryan standard-RSV) were studied by complement-fixation (CF) and transplantation tests. Approximately 50% of the induced tumors contained CF antigen specific for the avian sarcoma-leukosis group of viruses when examined with high-titer rabbit antiserum against sodium lauryl sulfate-treated avian myeloblastosis virus. Common specific transplantation antigen was found in all but one tumor. No correlation was observed between the presence of transplantation and CF antigen. Four tumors were positive in both CF and transplantation tests. Three tumors were positive in transplantation but negative in CF tests. One tumor was positive in CF tests, but negative in transplantation tests. Injection of CF positive mouse tumors in chickens caused chicken Rous sarcomas. No Rous sarcomas appeared in chickens injected with CF negative tumors. The only exception to this rule was a tumor induced by Bryan standard strain of RSV. This tumor contained CF antigen but gave negative results after injection in chickens. The possible significance of antigenic markers for studies of different types of virus-cell interaction is discussed.
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