Abstract
A swine influenza virus (A/swine/ Taiwan/70) was shown to be antigenically identical with human A2/Hong Kong/68. It readily infected volunteers and stimulated anti-hæmagglutinin and antineuraminidase antibodies. These antibodies reacted both with the infecting strain and with A2/Hong Kong/68. Clinical reactions were, however, modified in comparison with those of human A2/Hong Kong/68 or with those of a recent antigenic variant, but the reactions were still more severe than would be acceptable in a live vaccine. In contrast, two other " classical" swine viruses, immunologically distinct from the Hong Kong strain, possessed only low human infectivity. It is suggested that large outbreaks of human influenza may be caused by major variants originating in animals.
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