Abstract
Abstract Following differential centrifugation or zinc acetate precipitation, it was possible to fractionate rabies-infected tissue culture fluids into components which exhibited different complement-fixing, protective and immunogenic activities. The virion-depleted fraction showed higher complement-fixing activity than the fraction which contained essentially all the virions. The virion-depleted fraction obtained after precipitation of the virus with zinc acetate showed, in addition to complement-fixing activity, good protective activity. Thus, it is possible to produce material which contains a minimum quantity of infectious virus, is immunogenic and induces protection against challenge with virulent virus.
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