Abstract
We evaluated B memory responses in healthy adult volunteers who received one oral dose of live-attenuated Shigella flexneri 2a vaccine. LPS-specific B M cells increased from a median of 0 at baseline to 20 spot forming cells (SFC)/10 6 expanded cells following vaccination ( p = 0.008). A strong correlation was found between post-vaccination anti-LPS B M cell counts and peak serum anti-LPS IgG titers ( rs = 0.95, p = 0.0003). Increases in B M specific for IpaB approaching significance were also observed. In sum, oral vaccination with live-attenuated S. flexneri 2a elicits B M cells to LPS and IpaB, suggesting that B M responses to Shigella antigens should be further studied as a suitable surrogate of protection in shigellosis.
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