Abstract
AbstractConcanavalin A (Con A) has been shown to act differently on bone marrow‐derived (B) cell responses to antigen in vitro depending on the presence or absence of thymus‐derived (T) cells. When T cells were present, Con A suppressed the immune response to polymeric flagellin (POL) of Salmonella adelaide (a T‐independent antigen) and sheep erythrocytes (SRBC) (a T‐dependent antigen). In contrast, when T cells were absent, Con A enhanced the anti‐POL response and allowed an otherwise very low anti‐SRBC response to return to normal levels. Con A inhibited POL‐induced capping in a manner that was apparently independent of the presence of T cells. In a number of cases, the effects noted with Con A were also found with another mitogen, phytohemagglutinin. Some possible implications of these findings on the mechanism of T‐B cell collaboration and the relationship between capping and immune induction are discussed.
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