Abstract
Keratinocytes not only form physical barriers, but also have important immunologic functions. They can express antigen presentation-related molecules(such as major histocompatibility complex class Ⅱ(MHC-Ⅱ)and intercellular adhesion molecule-1)with changes of MHC-Ⅰ levels, in some disorders or after stimulation by cytokines such as interferon-γ. In addition, some studies have indicated that activated keratinocytes can process and present endogenous or exogenous antigens to activate antigen-specific T-lymphocytes. This function of keratinocytes is of great significance in elucidating the pathogenesis of related skin diseases and developing specific targeted therapy. Compared with classical antigen-presenting cells, the antigen-presenting function of keratinocytes is somewhat limited. Key words: Keratinocytes; Antigen presentation; T-lymphocytes; Major histocompatibility complex; Cell adhesion molecules
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