Abstract
Antigen challenge and airway remodeling in mice
Highlights
Chronic inflammation and a significant amount of airway remodeling are commonly seen in asthmatics and are thought to contribute to the severity of the disease
BALB/c mice were sensitized with ovalbumin (OA) and the kinetics of airway inflammation and remodeling processes following OA aerosol challenge were determined
Increases in IL-4, IL-5, and cellular fibronectin were detected in the Bronchoalveolar lavage fluid (BAL) in both models, but were more significant in the chronic model
Summary
Chronic inflammation and a significant amount of airway remodeling are commonly seen in asthmatics and are thought to contribute to the severity of the disease. Antigen challenge and airway remodeling in mice Aff[1] The University of Chicago, IL, USA
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