Abstract
Abstract Spleen, thymus and peritoneal cells of immunized mice were incubated with radioactive antigens and studied by autoradiography. A small number of lymphocytes in the spleen (0.1% to 0.5%) but very few in the thymus (0.01%) bind radioactive hemocyanin. The binding of antigen to lymphocytes apparently takes place by antibody receptors on their membranes. Exposure of most lymphocytes to antibodies to Ig blocked the binding. It was also found that the number of cells binding weak or strong immunogens was similar. Lymphocytes have been found that bind an autologous antigen, murine growth hormone. No lymphocytes bind mouse albumin. Incubation of spleen cells from immune or non-immune mice with highly radioactive KLH in vitro suppressed the capacity of the cells to adaptively transfer an immune response in x-irradiated mice. The inactivation of the adoptive immunity was specific since the treated cells made antibody to unrelated antigens. Macrophages took up radioactive antigen and this uptake was not blocked by exposure to anti-Ig.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
