Antigastric ulcer activity of Ludwigia octovalvis (Jacq.) P. H. Raven (ONAGRACEAE) hydroalcoholic extract

Abstract

Ludwigia octovalvis is used to treat stomachache in Malagasy traditional medicine. The present study was carried out to evaluate the anti-ulcer activity of its hydroalcoholic leaf extract in rats. Pylorus ligation and indomethacin-induced models were used to evaluate its anti-secretory and mucoprotective activities. Cimetidine (100 mg/kg) and Misoprostol (1.43 µg/kg) were used as the standard drugs. The extract was administered orally at doses 150, 300 and 600 mg/kg. The extract exhibited significant ulcer inhibition in indomethacin-induced ulcer model. The lesion surface area of the control group mucosa is equal to 6.2 ± 0.50 mm2, versus 4.32 ± 0.1, 2.75 ± 0.10 and 1.12 ± 0.05 mm2 in rat treated with the extract, and 2.1 ± 0.1 mm2 for the rats treated with misoprostol (p<0.05). It also reduces the gastric content acidity, which is equal to 2.79 ± 0.1 in control group, to 3.13 ± 0.1, 3.25 ± 0.2 and 5.31 ± 0.2 in the animals treated with the extract and 5.79± 0.1 for the animals treated with cimetidine (p<0.05). The extract showed significant reduction in mucosa lesion surface area and gastric content acidity, dose dependent compared to control.