Abstract
Bioactivity-directed fractionation of the CH 2Cl 2/MeOH (2:1, v/v) extract of the roots of Petiveria alliacea, using mutant yeast strains of Saccharomyces cerevisiae and fungi Cladosporium cladosporioides and C. sphaerospermum led to the isolation of dipropyl disulphide ( 1), dibenzyl sulphide ( 2), dibenzyl disulphide ( 3), dibenzyl trisulphide ( 4), dibenzyl tetrasulphide ( 5), benzylhydroxymethyl sulphide ( 6) and di(benzyltrithio) methane ( 7). Of these, 5– 7 are new compounds and this is the first report of the natural occurrence of 2 and 3.
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