Abstract
Evaluate the antifungal effect of some medicinal plant extracts (peppermint, rue, pomegranate and garlic) and their anti–adherent effect on C. albicans cells that attached on the fitting surface of acrylic resin denture base. Materials and Methods: This study evaluated the antifungal effect of plant extracts, using broth micro dilution method at two concentrations for each one. The visualization, in-spection and enumeration of adherent C. albicans cells and the detection of the anti–adherent effect of these plant extracts was achieved by using fluorescent microscope. For each plant extract, two concen-trations in addition to the time of immersion at three different intervals (1 h, 24 hrs and 48 hrs) were evaluated for the anti–adherent effect. Result: Antifungal effect of plant extracts on candida albicans cells, was measured by spectrophotometer which showed that both rue and pomegranate extracts had the best antifungal effect at first concentration, while in the second concentration, pomegranate and garlic extracts had the best antifungal effect . The mean number of remaining C. albicans cells which adhered on acrylic resin samples after treatment by immersion in the first concentration of plant ex-tracts for one hour was (3.1), (3.7), (3.7) and (4.7)] cells /mm2 respectively; while after treatment with second concentration of plant extracts for one hour was [ (4), (4.4), (4.4) and (4)] cells / mm2 respec-tively for the above mentioned plant Conclusion: All examined medicinal plant extracts were signifi-cantly effective in dislodging C. albicans cells from acrylic resin samples at their different concentra-tions and statistically there was no significant difference among the different times of immersion.
Highlights
The increased incidence of oral candidiasis among patients wearing dentures and other removable appliances is associated with a great increase in number of Candida that can be cultivated from the www.rafidaindentj.netKassab-Bashi T
Mouth[1],mostly in patients who wear complete dentures and have less than ideal mouth care.[2]. Recently, there has been an increased interest in antimicrobial agents from medicinal plants which have been used in folk medicine .(3,4) Antibiotics are produced either synthetically or through microbial fermentation, plants, may provide additional source for antimicrobial substances. [5,6] Much of work has been performed to screen the antimicrobial effect of many plants [7] and for the isolation of their active ingredients [8]: 1-Peppermint:The antimicrobial activity of volatile oil isolated from peppermint has an inhibitory effect on the growth of large numbers of bacteria, yeasts including Candida[9]
4-Garlic(Allium sativum):Garlic has antibacterial, antifungal, antiviral properties [12,16],its inhibitory effect against C. albicans by inhibiting its adhesion to buccal epithelial cells and reduces germ tube formation
Summary
The increased incidence of oral candidiasis among patients wearing dentures and other removable appliances is associated with a great increase in number of Candida that can be cultivated from the www.rafidaindentj.netKassab-Bashi T. 4-Garlic(Allium sativum):Garlic has antibacterial, antifungal, antiviral properties [12,16],its inhibitory effect against C. albicans by inhibiting its adhesion to buccal epithelial cells and reduces germ tube formation. For this reason, it is effective in the treatment of chronic atrophic candidiasis.[17]The aim of this study is to evaluate the antifungal anti-adherent effectof medicinal plant extracts (peppermint,rue, pomegranate and garlic) on the colonization of C. albicans on acrylic resin denture base surface ( An in vitro study)
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