Abstract
Objective: To assess the antifungal effect of Nigella sativa extract on female Wistar rats vulvovaginal candidiasis.
 Methods: This was an analytic study that assess the therapeutic effect of Nigella sativa in rats’ vulvovaginal candidiasis model. The subjects were 28 rats that had been inoculated with Candida albicans and divided into 4 groups: control group (G1), fluconazole group (G2), Nigella sativa group (G3) and combination of Nigella sativa with fluconazole group (G4). Candida albicans colony was measured to assess the therapeutic effect of the treatment.
 Results: There were no difference number of Candida albicans colony between all group before inoculation (p = 0,274) and after inoculation (p = 0,323). There were a significant decreased number of Candida albicans colony on the 72 h after the treatment between the three types of treatment with the control group (Nigella sativa group p = 0,002; Fluconazole group p = 0,001; Nigella sativa+fluconazole p = 0,001)
 Conclusion: Nigella sativa has a potential antifungal effect by reducing the number of Candida albicans colonies.
Highlights
Candida species are one of the commonest causes of vaginitis in healthy women of reproductive age
Nigella sativa is a member of the Ranunculaceae family and has been used as a natural food and medicine which grows in Asia and the Middle East [4]
This experimental research was conducted in July-October 2019 on Animal House-Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara to asses the antifungal effect of Nigella sativa extract on vulvovaginal candidiasis
Summary
Candida species are one of the commonest causes of vaginitis in healthy women of reproductive age. Vulvovaginal candidiasis (VVC) is characterized by vulvovaginal itching, redness and discharge. Candida albicans is the most common fungal infection of humans, causing Candidiasis [1]. Complications of vulvovaginalis candidiasis (VVC) that often occur is a pelvic inflammatory disease which can cause infertility in sexually active women and chorioamnionitis which leading miscarriage or premature birth in women who are pregnant. Nigella sativa is a member of the Ranunculaceae family and has been used as a natural food and medicine which grows in Asia and the Middle East [4]. It contains Thymoquinone, Thymohydroquinone, Dithymoquinone and Thymol. Nigella sativa has pharmacological effects as antimicrobial, antiinflammatory, immune stimulation and anti-cancer properties [5, 6]
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