Antifungal effect and characterization of denture PMMA-nanocomposite containing gold, platinum and silver nanoparticles

Abstract

This study assessed the antifungal effect of modified denture acrylic resin containing Au, Pt and Ag nanoparticles (NPs) respectively and evaluated their physical aspects to produce a antimicrobial nanocomposite material. Each colloidal NPs suspension was preliminary combined to the denture powder in different doses (0, 10, 50, 100 and 200 ppm) then mixed with monomer. The antifungal (C. albicans) effect was assessed using a fluorescence activated cell sorting, thermal analysis and color stability test were conducted to characterize those nanocomposites. As compared to control (0 ppm), the significant reductions of viable cell adherence on the nanocomposite were shown at the dose of 200 ppm in all NPs and 100 ppm in AgNPs. Addition of NPs to PMMA resulted in successful co-polymerization phase with stable thermal property, however, lack of color stability should be improved.