Abstract
With the development of a standardized broth macrodilution reference method for in-vitro testing of Candida spp. and Cryptococcus neoformans, it is now possible to correlate antifungal drug minimum inhibitory concentrations with clinical outcome, and to establish interpretive breakpoints for different infections. More convenient methods (broth microdilution and agar diffusion) of testing are now being evaluated by comparison with the standard reference method, and modifications of this procedure also appear promising for the in-vitro testing of filamentous fungi.
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