Abstract
Antifungal activity guided fractionation of solvent extracts of the stem bark of Bridelia retusa of the family Euphorbiaceae against Cladosporium cladosporioides, furnished new bisabolane sesquiterpenes, ( E)-4-(1,5-dimethyl-3-oxo-1-hexenyl)benzoic acid, ( E)-4-(1,5-dimethyl-3-oxo-1,4-hexadienyl) benzoic acid, ( R)-4-(1,5-dimethyl-3-oxo-4-hexenyl)benzoic acid and (−)-isochaminic acid, together with the known ( R)-4-(1,5-dimethyl-3-oxohexyl)benzoic acid (ar-todomatuic acid), 5-allyl-1,2,3-trimethoxybenzene (elemicin), (+)-sesamin and 4-isopropylbenzoic acid (cumic acid). All these compounds showed fungicidal activity on TLC bioautography method at very low concentrations except elemicin.
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