Abstract
Extracts from the dried pericarp of Sapindus saponaria L. (Sapindaceae) fruits were investigated for their antifungal activity against clinical isolates of yeasts Candida albicans and C. non-albicans from vaginal secretions of women with Vulvovaginal Candidiasis. Four clinical isolates of C. albicans, a single clinical isolated of each of the species C. parapsilosis, C. glabrata, C. tropicalis, and the strain of C. albicans ATCC 90028 were used. The hydroalcoholic extract was bioactivity-directed against a clinical isolate of C. parapsilosis, and showed strong activity. The n-BuOH extract and one fraction showed strong activity against all isolates tested. Further column-chromatography on silica gel separation of this fraction afforded two pure triterpene acetylated saponins: 3-O-(4-acetyl-beta-D-xylopyranosyl)-(1->3)-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranosyl-hederagenin (1) and 3-O-(3,4-di-acetyl-beta-D-xylopyranosyl)-(1->3)-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabynopyranosyl-hederagenin (2). The structures of the compounds were based on spectral data ((1)H and 13C NMR, HSQC, HMBC and MS), and on with literature. The saponins isolated showed strong activity against C. parapsilosis.
Highlights
Species from Sapindaceae family are known for their traditional medicinal uses as a diuretic, stimulant, expectorant, natural surfactant, sedative, vermifuge and against stomachache and dermatitis in many parts of the world
Sapindus saponaria L. (Sapindaceae), popularly known as ‘sabão-de-soldado’ and ‘saboeiro’, is a medium-sized deciduous tree occurring in the tropics, e.g., America and India, where the fruit is used as a soap and as a remedy against ulcers, scabies, joint pain, inflammations (Braga 1984, Abdel-Wahab and Selim 1985, Corrêa 1984, Albiero et al 2002) and skin lesions caused by fungi (Murgu and Rodrigues-Filho 2006)
The n-BuOH extract and a subfraction were tested against Candida albicans, C. glabrata, C. parapsilosis, C. tropicalis and C. albicans ATCC 90028
Summary
Species from Sapindaceae family are known for their traditional medicinal uses as a diuretic, stimulant, expectorant, natural surfactant, sedative, vermifuge and against stomachache and dermatitis in many parts of the world. We describe the in vitro antifungal activity of extracts and subfractions from dried pericarps of the fruits of S. saponaria, as well as of the bioactivity-directed isolated saponins (1) and (2). ANTIFUNGAL ACTIVITY OF THE EXTRACTS AND SAPONINS FROM Sapindus saponaria L.
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