Abstract
Three hydroxyflavan phytoalexins and 23 other flavonoid compounds variously substituted in their homocyclic rings were assessed for antifungal activity against Botrytis cinerea and Cladosporium herbarum using sporeling and TLC plate bioassays. The pairs of optical isomers of two of the phytoalexins possessed similar activity. The isoflavan analogue of the phytoalexin 7-hydroxyflavan was active. Most fungitoxic compounds had not more than one or two polar substituents and methylation of all of these groups removed activity. The basis of the antifungal activity of flavonoids is discussed.
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