Antifungal Activity of Denture Soft Lining Material Modified by Silver Nanoparticles—A Pilot Study

Grzegorz Chladek,Jan Łukaszczyk,Izabela Barszczewska-Rybarek,Jarosław Żmudzki,Wojciech Król,Teresa Nalewajek,Anna Mertas

doi:10.3390/ijms12074735

Abstract

Soft liner materials in oral cavity environments are easily colonized both by fungi and dental plaque. These factors are the cause of mucosal infections. The microorganism that most frequently colonizes soft liner materials is Candida albicans. Colonization occurs on the surface of materials and within materials. A solution to this problem might involve modification of soft liner materials with silver nanoparticles (AgNPs). In this article, we present results showing the antifungal efficacy of silicone soft lining materials modified with AgNPs. The modification process was conducted by dissolving both material components (base and catalyst) in a colloidal solution of AgNPs and evaporating the solvent. Composites with various AgNP concentrations (10, 20, 40, 80, 120 and 200 ppm) were examined. The in vitro antifungal efficacy (AFE) of composite samples was 16.3% to 52.5%.

Highlights

Denture wearing favors the occurrence of stomatopathy by increasing both the number of local injuries and the time that the mucosa is in contact with microorganisms [1,2]
We present a method of incorporating AgNPs into the chemically cured silicone soft liner material Ufi Gel SC (UG)
No hexane from the modification process was detected on 1H NMR spectra made for samples of composites, base UG/AgNPs and catalyst UG/AgNPs

Summary

Introduction

Denture wearing favors the occurrence of stomatopathy by increasing both the number of local injuries and the time that the mucosa is in contact with microorganisms [1,2]. Budtz-Jorgensen et al [3] report that 50% of complete and partial denture wearers experience problems with stomatopathy. Soft liner materials are usually used for denture relining to evenly distribute the loads transferred onto soft tissues during motion. Soft structures should increase the comfort of denture wearers and support prosthetic treatment. They are primarily used in patients with thin atrophic mucosa, in patients with normal mucosa with an atrophied ridge, in patients with a sharp alveolar ridge and when the mucosa exhibits a low tolerance to the load applied by the dentures [5,6]. The specific mechanical characteristics of soft liners facilitate their use in other non-conventional applications [7]

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