Antifungal Action of Thyme and Basil Extracts on Different Denture Base Materials

Abstract

Statement of problem: The use of medical plants has expanded as a result of increased resistance of microbes to chemical medications, as well as their negative effects and excessive costs. Ocimum basilicum (basil) and Origanum Syriacum (Thyme), were studied for their antifungal activities against Candida albicans (C. albicans) species. Purpose: The goal of this study is to see if two plant extracts, Ocimum basilicum (basil) and Origanum Syriacum (Thyme), have antifungal effects on different denture base materials (long cycle heat-polymerized methyl methacrylate PMMA, short cycle heat-polymerized PMMA, and thermoplastic monomer free microcrystalline polymer karadent). Material and methods: Plant extracts (basil and thyme) were tested for antifungal activity using the pores method. The effect of plant extracts on various denture base surfaces was determined using a disc diffusion test. Fifty-four discs of 6mm diameter and 2mm thickness were prepared from long cycle heat-polymerized methyl methacrylate PMMA, short cycle heat-polymerized PMMA, and thermoplastic monomer free microcrystalline polymer karadent and distributed into three groups:-ve control, basil, and thyme. The diameter of growth inhibition zones was determined after these discs were placed on a Sabouraud Dextrose agar surface and incubated for 24 hours at 37 C. Results: Both Origanum syriacum, and Ocimum basilicum were efficient against Candida albicans. Origanum Syriacum extracts showed a superior antifungal effect compared to the Ocimum basilicum extract with long and short curing cycle acrylic resin, but in Karadent the values of Ocimum basilicum were higher than those of Origanum syriacum extract.