Abstract
Hyperbranched polyglycerols (HPG) bearing terminal thiol moieties (HPG-SH) were synthesized via anionic-ring-opening multibranching polymerization of glycidol from pentaerythritol and subsequent 1,1′-carbonyldiimidazole (CDI) coupling with cysteamine. Bioinspired (1) N-dopamine maleimide (DM), (2) tannic acid (TA), and (3) polydopamine (PDA) were employed to produce monolayer, multilayer, and polymeric anchors, respectively, on stainless-steel (SS) substrates. Postfunctionalization of the biomimetic anchor-modified SS surfaces was enacted by tethering of HPG-SH via Michael addition or thiol–ene “click” reaction to confer surface hydrophilicity. The thickness and grafting density of HPG coatings could be controlled by tuning the degree of thiolation. In comparison to the pristine SS surface, the HPG-modified surfaces exhibited substantially reduced initial adhesion and inhibition of the biofilm formation of Gram-negative Pseudomonas sp. and Gram-positive Staphylococcus epidermidis. Qualitative and quantita...
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
