Abstract
Superficial mycoses are among the main reasons for dermatological consultations, and dandruff is a common complaint of the majority of individuals at a given moment in life; such problems are caused and aggravated by fungi. With the objective of verifying what the demand is and which main antifungal drugs are used in dermatological products, all external use formulations produced at a prescription pharmacy in Londrina, Paraná State, during the first semester of 2006, were evaluated in this study. Among the different products, antifungals were the most requested, representing 17.19% of production. The most used active principles were: ketoconazole, zinc pyrithione, miconazole and gentian violet. During the months of February and March, a significant increase in demand was observed, especially on those products containing ketoconazole and miconazole. This suggests that in the summer, probably due to the heat and to the great frequency of people in swimming pools and beaches, the occurrence of mycoses is favored and, therefore, hygienic care should be redoubled. The increase in the incidence of fungal infections verified in the last decades should be a stimulus to search for new effective antifungal agents with fewer adverse effects and with low cost to help in the treatment of such cutaneous alterations.
Highlights
A pele e suas estruturas anexas - pelos e unhas, juntamente com glândulas, músculos e nervos compõem o sistema tegumentar
As micoses superficiais foram apontadas como uma das principais tanto no setor público como no setor privado, e em todos os grupos etários avaliados (SBD, 2006)
Journal of the American Academy of Dermatology, v
Summary
Com o objetivo de verificar qual a demanda e quais os principais antifúngicos utilizados em produtos dermatológicos, foram avaliadas, neste estudo, todas as formulações de uso externo produzidas em uma farmácia de manipulação na cidade de Londrina, Estado do Paraná, no primeiro semestre de 2006. Foi observado aumento significativo na demanda, nos meses de fevereiro e março, em especial dos que contém cetoconazol e miconazol, sugerindo no verão, provavelmente, pelo calor e a maior frequência das pessoas nas piscinas e praias, a ocorrência de micoses é favorecida e por isso os cuidados higiênicos devem ser redobrados. O aumento na incidência de infecções fúngicas verificado nas últimas décadas deve servir de incentivo na busca de novos agentes antifúngicos eficazes, com menores efeitos adversos e de baixo custo, que auxiliem no tratamento de tais alterações cutâneas.
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