Abstract

THE use of halogenated pregnene derivatives, especially of 9α-fluoro-hydrocortisone, has been undoubtedly the greatest recent advance in the experimental pharmacology of steroids, as evidenced by the outstanding work of Fried and his colleagues1 on the various potencies of this corticoid. In the present communication we discuss results obtained in guinea pigs, in which we tried to prevent the abdominal fibromatogenic action of œstrogen; other antiœstrogenic potencies also have been studied.

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