Abstract
A C-22 derivative of F 2α-ICI 74205, was found to be five times more active than F 2α by s.c. route and 20 times by oral route in terminating early pregnancy in hamsters. The compound inhibited decidual cell reaction which could be restored to normal level by exogenous progesterone. It caused histologic degeneration of luteal tissue and induced fresh ovulations in pregnant hamsters. The compound neither interfered with implantation as evidenced by the occurrence of normal Pontamine blue reaction in the treated animals nor did it significantly affect egg transport. The data suggest that lengthening of the lower side chain results in an increased antifertility activity of the molecule.
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