Abstract
Acacetin and luteolin, the flavones isolated from the whole plant S. lutea. have been investigated for endocrine and contraceptive properties in the pre-implantation stage of pregnancy. Graded doses of these compounds, in gum acacia suspension, by oral administration from day 1 to day 4 of pregnancy showed dose-dependent antiimplantation activity (5–25 mg/kg body weight/day). MED 100 was found to be 25 mg/kg body weight in the day 1–4 regimen in rats for both the compounds. In another study, a single oral dose of these compounds (10 mg/kg body weight) on day 1, 2 or 3 of pregnancy prevented 100% implantation. The compounds exhibited estrogenic property at their contraceptive dose level but failed to show antiestrogenic activity.
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