Antifertility and dominant lethal mutation studies in male rats with [formula omitted]-α-chlorohydrin and an amino-analogue

Abstract

Low doses of dl -3-chloro-1,2-propanediol (α-chlorohydrin) and the amino analogue ( dl -1-amino-3-chloro-2-propanol) produce sterility in rats by an effect on epididymal spermatozoa. The hazard of associated genetic damage after exposure to these two compounds and also to the individual stereo-isomers of the amino-chlorohydrin has been investigated in male rats by the dominant lethal assay. Negative results were obtained with all four substances. Unlike α-chlorohydrin, however, the amino-compounds over a range of dose levels were unable to produce group sterility in the male Wistar rats used. Single dose treatment also clearly demonstrated that dl -α-chlorohydrin was many times more effective in producing permanent sterility.