Abstract

The emphasis in this review is upon agents influencing postcoital events. Drugs discussed exert their effects upon the central nervous system, peripheral hormonal organs, fertilization, tubal transport, blastocyst implantation, and the zygote. The relationships between estrogenic, antiestrogenic, and antifertility activities of the drugs are discussed. The peculiarities of the nonsteroidal compounds may be due to the period of time they occupy receptors in the uterus or other target organs. Special attention is given to stilbene and bibenzyl derivatives; basic ether derivatives of DMS and related compounds; and U-11,100A, U-11,555A, and similar compounds.

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