Abstract
Objective: The objective was to investigate the male antifertility effect of Decaschistia crotonifolia leaf extract on male Wistar rats.
 Methods: The animals were divided into three groups of five animals each. The first group (I) served as control and received normal saline, and remaining Groups II and III were treated with plant extract at a dose of 200 and 400 mg/kg p.o., respectively, for 21 days.
 Results: Dose-dependent significant decrease in the weight of testes and epididymis was observed. Furthermore, a dose-related reduction in sperm count and motility was observed. A significant decrease in testosterone levels leading to infertility was also observed.
 Conclusion: The 70% methanolic leaf extract of D. crotonifolia has produced dose-dependent antifertility effect on male rats.
Highlights
Fertilization and control of overpopulation is a major quest in the modern era
As a part of contribution to the society, the present paper is focused on the research activity of Decaschistia crotonifolia for its antifertility activity
Findings showed that the methanolic leaf extract of D. crotonifolia could significantly alter the male fertility potentials
Summary
Fertilization and control of overpopulation is a major quest in the modern era. Majority of people are facing problems such as infertility due to unremarkable reasons, and on the other hand, control of fertilization is one of the targets of scientific community. A number of oral antifertility agents [1] are available in market, their usage is questionable due to their synthetic nature and a wide variety of side effects. One of the most attracting and safest ways is using herbal medicine which is having a promising output with less or no side effects from the ancient times [2]. A majority of scientific and systemic investigations on herbal plants for their physicochemical and phytopharmacological properties including their antifertility activities are undertaken by researchers worldwide. As a part of contribution to the society, the present paper is focused on the research activity of Decaschistia crotonifolia for its antifertility activity
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