Abstract
Summary. The antifertility effect of 5-hydroxytryptamine creatinine sulphate (5-HT), 20 to 40 mg/kg subcutaneously, given about the time of implantation, was investigated in four species having between them three modes of implantation. The compound had a marked antifertility effect in rats once implantation had occurred but did not have any effect in mice, which have a similar mode of implantation, or any significant effect in guinea-pigs and rabbits on or around the day of implantation. In rats, antifertility effects similar to those seen with 5-HT were obtained by occluding the uterine vasculature for 1 hr, i.e. maximum effects on the day of implantation and little effect before this. In view of this and the finding that the effects of 5-HT were considerably reduced by the intraperitoneal injection of 40 mg dipyridamole/kg 15 min later, it was concluded that 5-HT produced its effects by reducing blood flow in the uterus.
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