Abstract
Ethnopharmacological relevance: Traditionally, Mimosa pudica Linn. (Fabaceae) is used for its anti-inflammatory, sedative, anxiolytic, antioxidant and antifatigue properties. Aim: To determine the antifatigue effects of Mimosa pudica aqueous extracts in experimental model of weight loaded force swimming test. Materials and methods: Mice were divided into seven groups and treated for 28 consecutive days as follows: groups one and two received orally distilled water (10 mL/kg) and served as normal group and negative control group, respectively. Groups three to six, (test groups) received orally graded doses of Mimosa pudica (20, 40, 80 and 160 mg/kg) and group seven (positive control) received vitamin C (50 mg/kg), respectively. One hour after the treatment, mice were subjected to the weight loaded force swimming test with tail load, except for the normal group; and the swimming duration, body weight, food and water intake were measured. Twenty-four hours after the last treatment the serum level of noradrenaline, dopamine and serotonin, and the relative organs weight were measured. Results: Mimosa pudica aqueous extracts significantly and dose-dependently increased the swimming duration and the weight of heart and lungs. The extracts did not induce a significant variation in the level of food and water intake, body weight, and serum of noradrenaline, dopamine and serotonin. Conclusion: Pretreatment of mice with Mimosa pudica aqueous extracts was observed to have better antifatigue properties mediated via amelioration of swimming capacity and physical aptitude in the weight loaded force swimming model.
Highlights
Training program is designed to ameliorate the performances of sports performers and to reduce the duration of the recovery processes minimize fatigue [1, 2]
Pretreatment of mice with Mimosa pudica aqueous extracts was observed to have better antifatigue properties mediated via amelioration of swimming capacity and physical aptitude in the weight loaded force swimming model
Effects of Mimosa pudica aqueous extracts on swimming duration in mice subjected to weight loaded force swimming test The results indicated a significant difference in the delay of fatigue after four weeks of swimming test [F(6, 35) = 959.5; P
Summary
Training program is designed to ameliorate the performances of sports performers and to reduce the duration of the recovery processes minimize fatigue [1, 2]. The increased effort in sustained training program and decreased recovery period trigger fatigue and limit performances. The new determinant of sports performance relied mostly on dietary supplements or energetic drink from plant extract to enhance exercise capacity and improve performance [4, 5]. Accumulation of metabolic waist (lactic acid and amino acid) causing acidosis and inhibits enzymatic reactions and modification of the ionic equilibrium of membrane; deterioration of muscles fibres and weakness of neurotransmitters [13, 14]. These two types are seen to be strongly linked [12, 15]
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