Anti-fatigue Effect of Polysaccharides from Pleurotus eryngii in Aged Mice

Abstract

Objective:To study the anti-fatigue effect of Pleurotus eryngii polysaccharides in aged mice.Methods:Healthy male Kunming mice were randomly divided into control group(A),aging model group(B) and Pleurotus eryngii polysaccharide treated aging group(C).The mice in Group B and C were intraperitoneally injected D-galactose at the dose of 100 mg/(kg bw·d) and those in Group A were intraperitoneally injected at the same volume of saline for 60 consecutive days.The mice in Group C were administered Pleurotus eryngii polysaccharides at the dose of 100 mg/(kg bw·d) and the mice in Group A and B were given distilled water from day 41.After the administration for 20 consecutive days,all mice were subjected to exhaustive swimming and exhaustive swimming time was recorded.Meanwhile,blood was harvested for determining the contents of blood urea nitrogen,lactate and hemoglobin and organ indexes were also measured.Results:The fungal polysaccharides prolonged exhaustive swimming time of aged mice,decreased blood urea nitrogen and lactate levels,and significantly increased hemoglobin content,red blood cell number,and thymus and spleen indexes.Conclusion:Pleurotus eryngii polysaccharides have an obvious anti-fatigue effect and improve exercise capacity of mice.