Antiepileptic action of excitatory amino acid antagonists in the photosensitive baboon, papio papio

Abstract

Antagonists of excitation induced by dicarboxylic amino acids have been evaluated for acute anticonvulsant activity in baboons, Papio papio, with photosensitive epilepsy. 2-Amino-7-phosphonoheptanoic acid, 1 mmol/kg, i.v., abolishes myoclonic responses for 5 h. Less prolonged protection is seen after cis-2,3-piperidine-dicarboxylic acid, 1–3.3 mmol/kg: 2-amino-5-phosphonovaleric acid, 1–3.3 mmol/kg; or glutamic acid diethyl ester, 1–3.3 mmol/kg. Toxic side-effects are prominent after the latter two compounds. Antagonists of excitation due to N-methyl- d-aspartate posses acute anticonvulsant activity in a wider range of models epilepsy.