Abstract
Ixodes ricinus transmits bacterial, protozoal and viral pathogens, causing disease and forming an increasing health concern in Europe. ANTIDotE is an European Commission funded consortium of seven institutes, which aims to identify and characterize tick proteins involved in feeding and pathogen transmission. The knowledge gained will be used to develop and evaluate anti-tick vaccines that may prevent multiple human tick-borne diseases. Strategies encompassing anti-tick vaccines to prevent transmission of pathogens to humans, animals or wildlife will be developed with relevant stakeholders with the ultimate aim of reducing the incidence of tick-borne diseases in humans.
Highlights
Tick-borne diseases as a public health concern in Europe Ixodes ricinus is a hard tick that transmits a variety of pathogens of medical and veterinary importance
The most pathogenic infection is caused by tick-borne encephalitis virus (TBEV), with 1 to 2% of patients reportedly dying from the European subtype [2], and with up to 46% of TBE patients suffering from long-term sequelae [3]
Infection of most other tick-borne pathogens associated with I. ricinus, such as Babesia spp., and B. miyamotoi, is usually mild and may go undiagnosed
Summary
Tick-borne diseases as a public health concern in Europe Ixodes ricinus is a hard tick that transmits a variety of pathogens of medical and veterinary importance. Whether anti-tick vaccines can be used to (locally) eradicate I. ricinus, and prevent human tick-borne diseases remains to be established.
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