Abstract
Letters18 September 2012Antidiuretic Hormone Antagonist to Reduce Cystine Stone FormationHans de Boer, MD, PhD, Anita Roelofsen, MD, and Pim M.W. Janssens, PhDHans de Boer, MD, PhDFrom Rijnstate Hospital, 6881 NR Arnhem, the Netherlands.Search for more papers by this author, Anita Roelofsen, MDFrom Rijnstate Hospital, 6881 NR Arnhem, the Netherlands.Search for more papers by this author, and Pim M.W. Janssens, PhDFrom Rijnstate Hospital, 6881 NR Arnhem, the Netherlands.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-6-201209180-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Cystinuria is the most common inherited cause of recurrent kidney stones (1). Its principal disorder is impaired reabsorption of cystine in the proximal renal tubule. As a result, large amounts of cystine are excreted in urine, kidney stones form because cystine is poorly soluble, and the patient experiences many urologic interventions. Measures to prevent stone formation include changing the diet to reduce cystine excretion, diluting urine to a lower cystine concentration, and making the urine alkaline to improve cystine solubility. Cystine-binding thiol drugs also improve cystine solubility but need to be discontinued because of adverse effects in 30% to ...
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