Abstract
The renal and cardiovascular actions of intravenous injection or infusion of prostaglandin E 2 (PGE 2) have been investigated in the anaesthetised rainbow trout, Salmo gairdneri. Amounts of 1–2500 ng PGE 2/kg body wt had a potent vasodilatory action and caused rapid dose-related decreases in dorsal aortic blood pressure. Intravenous infusion of PGE 2 was associated with a secondary tachycardia and vasoconstriction. Injection of PGE 2 resulted in transient dose-related decreases of urine production. Infusion of PGE 2 at 200 ng/min/kg rapidly decreased glomerular filtration rates by reducing the populations of filtering nephrons and later by increasing the renal tubular water reabsorption. The possible endocrine systems which may be involved in the renal responses to PGE 2 are discussed.
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