Abstract
ObjectiveTo investigate the antidiarrhoeal activity of 95% total alcoholic extract (TAE) and total aqueous extract (TAQ) of Carum copticum (C. copticum) seeds. MethodsAntidiarrhoeal activity of C. copticum seed extracts at a dose of 100 mg/kg BW was evaluated using experimentally induced castor oil diarrhoea, gastrointestinal transit of charcoal meal and enteropooling activity in male wistar rats and compared to standard drugs. ResultsAt a dose of 100 mg/Kg BW (TAQ and TAE) significantly decreased the diarrhoeal droppings in castor oil induced diarrhoea, the mean distance travelled by charcoal meal showed a significant reduction in the secretion of gastrointestinal fluid accumulation by 39.90% to 50.70%. C. copticum extracts on castor oil induced fluid accumulation showed a greater inhibitory effect on Na+ levels than on K+ concentrations. ConclusionsThese results suggest that C. copticum seed extracts could be used for the treatment of diarrhoea.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
